Biochip detection of KRAS,BRAF, and PIK3CA somatic mutations in colorectal cancer patients |
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Authors: | Emelyanova M. A. Amossenko F. A. Semyanikhina A. V. Aliev V. A. Barsukov Yu. A. Lyubchenko L. N. Nasedkina T. V. |
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Affiliation: | 1.BIOCHIP-IMB Ltd., Moscow, 117312, Russia ;2.Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia ;3.Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia ;4.Medical Genetic Research Center, Moscow, 115478, Russia ; |
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Abstract: | Molecular Biology - Somatic mutations of KRAS, PIK3CA, and BRAF cause insensitivity of colorectal tumors to therapy with anti-EGFR monoclonal antibodies, necessitating a genetic testing prior to... |
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