| STING信号通路的研究进展 |
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| 引用本文： | 庞晓燕,谭星,郝秀静,李敏.STING信号通路的研究进展[J].微生物学杂志,2022(4):109-116. |
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| 作者姓名： | 庞晓燕 谭星 郝秀静 李敏 |
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| 作者单位： | 1.宁夏大学 西部特色生物资源保护与利用教育部重点实验室，宁夏 银川 750021；2.宁夏大学 生命科学学院，宁夏 银川 750021 |
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| 基金项目： | 国家自然科学基金项目(31960036)；宁夏大学研究生创新项目(GIP2020046) |
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| 摘 要： | 干扰素基因刺激因子(Stimulator of interferon gene，STING)作为固有免疫系统的关键性接头蛋白，在外源或内源DNA介导的免疫应答中发挥重要作用，广泛参与宿主体内的多种信号传导过程。概述了STING信号通路分子机制及其在抗病毒感染、自身免疫疾病、神经系统疾病和肿瘤中的作用，介绍了常见的STING激动剂和抑制剂，以期为STING的进一步研究提供参考。
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| 关 键 词： | 干扰素基因刺激因子 固有免疫 适应性免疫 胞质DNA识别 免疫机制 |
Advances in STING Signaling Pathway |
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| PANG Xiao-yan,TAN Xing,HAO Xiu-jing,LI Min.Advances in STING Signaling Pathway[J].Journal of Microbiology,2022(4):109-116. |
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| Authors: | PANG Xiao-yan TAN Xing HAO Xiu-jing LI Min |
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| Institution: | 1. Key Lab. of Minist. of Educ. for Conserv. & Util. of Spec. Bio-Res. in W. China, Yinchuan 750021;2. Schl. of Life Sci., Ningxia Uni., Yinchuan 750021 |
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| Abstract: | Stimulator of interferon genes (STING), as a critical joint protein in innate immune system, plays a vital role in exogenous or endogenous DNA-mediated immune response, and is widely involved in a large variety of signal transduction processes in the host body. This article summarizes molecular mechanism of STING signaling pathway and its role in antiviral infection, autoimmune diseases, neurological diseases, and tumors, and introduces common STING agonists and inhibitors, so as to provide reference basis for further study on STING. |
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| Keywords: | stimulator of interferon gene (STING) innate immunity adaptive immunity cytoplasmic DNA recognition immune mechanism |
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