Noxa: a sweet twist to survival and more |
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| Authors: | Gimenez-Cassina Alfredo Danial Nika N |
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| Institution: | Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute, Boston, MA 02115, USA. |
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| Abstract: | The BCL-2 family member Noxa induces apoptosis by antagonizing the prosurvival protein MCL-1. In this issue of Molecular Cell, Lowman et al. (2010) uncover a glucose-dependent phosphoregulatory mechanism that inactivates Noxa's apoptotic function and triggers its capacity to modulate glucose metabolism. |
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