Regenerative ability of hepatocytes is inhibited in early stages of liver fibrosis. |
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Authors: | J Kanta A Chlumská |
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Institution: | Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové. |
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Abstract: | Female Wistar rats were given three doses of carbon tetrachloride, 10.4 mmol/kg of body weight. The doses were administered within 16 days and another 16 days were allowed to pass before partial (37%) hepatectomy was done. The liver showed very mild fibrosis at that time. DNA synthesis (measured by 3H-thymidine incorporation) was decreased by 53% and mitotic activity of hepatocytes was decreased by 56% when compared to olive oil-pretreated partially hepatectomized controls. The results show that the mitotic potential of hepatocytes in early stages of liver fibrosis is impaired which may influence the course of the disease. |
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