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Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells
Authors:Yumiko Abe  Hiromitsu Sinozaki  Takeshi Takagi  Takashi Minegishi  Koichi Kokame  Kenji Kangawa  Miki Uesaka  Kaoru Miyamoto
Institution:(1) Department of Gynecology and Reproductive Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan;(2) Education and Research Center of Graduate School of Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan;(3) National Cardiovascular Center Research Institute, Osaka, Japan;(4) Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Abstract:

Background  

Exposure to dioxins results in a broad range of pathophysiological disorders in human fetuses. In order to evaluate the effects of dioxins on the feto-placental tissues, we analyzed the gene expression in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated primary cultures of human amniotic epithelial cells.
Keywords:
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