Identification of a new gene responsible for the oxygen tolerance in aerobic life of Streptococcus mutans |
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Authors: | Yamamoto Y Higuchi M Poole L B Kamio Y |
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Affiliation: | Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. |
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Abstract: | Alkyl hydroperoxide reductase in Streptococcus mutans consists of two components, Nox-1 and AhpC. Deletion of nox-1 and ahpC in a double mutant as well as the wild-type of Streptococcus mutans can form colonies in the presence of air to the same extent. The evidence suggested the presence of some other antioxidant system(s) independent of the Nox-1/AhpC system in the bacterium. Here we identified a new antioxidant gene (dpr) and the gene product (Dpr) which complements the defect of peroxidase activity caused by the deletion of nox-1 and ahpC in S. mutans. The dpr-disruption mutant of S. mutans could form colonies anaerobically but not aerobically. |
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