Release of contractile agents from rat vas deferens by clonidine. |
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Authors: | N H Jurkiewicz A Jurkiewicz |
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Institution: | Department of Pharmacology, Escola Paulista de Medicina, S?o Paulo, Brazil. |
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Abstract: | Clonidine induces contractile effects on the isolated rat vas deferens, but not on rat uterus or guinea-pig ileum. However, we have observed that if clonidine is incubated for about 10 min with a nutrient solution containing an isolated rat vas deferens, the resulting solution can contract an isolated rat uterus, or guinea-pig ileum indicating the involvement of a substance released from the vas. This contractile effect was partially reduced by naloxone and by serotonin antagonists, and by using a denervated vas, indicating that opioids, serotonin and eventually other substances released from nerve tissue of the vas can be involved. |
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