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Regulation beyond genome sequences: DNA and histone methylation in embryonic stem cells |
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| Authors: | Wei Yang Qi Zhou Xiu-Jie Wang |
| Affiliation: | 1. State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;Graduate University of the Chinese Academy of Sciences,Beijing 100101,China 2. State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China 3. State Key Laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China |
| Abstract: | Embryonic stem (ES) cells distinct themselves from other cell type populations by their pluripotent ability. The unique features of ES cells are controlled by both genetic and epigenetic factors. Studies have shown that the methylation status of DNA and histones in ES cells is quite different from that of differentiated cells and somatic stem cells. Herein, we summarized recent advances in DNA and histone methylation studies of mammalian ES cells. The methylation status of several key pluripotent regulatory genes is also discussed. |
| Keywords: | Embryonic stem (ES) cells epigenetic DNA methylation histone methylation |
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