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Obtaining a high-activity strain capable of producing the antistaphylococcal antibiotic batumin |
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| Authors: | V. V. Smirnov L. N. Churkina V. I. Perepnikhatka N. S. Mukvich A. D. Garagulya E. A. Kiprianova A. N. Kravets S. A. Dovzhenko |
| Affiliation: | (1) Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 252143 Kiev, Ukraine;(2) Institute of Epidemiology and Infectious Diseases, Ukraine Ministry of Health, 252038 Kiev, Ukraine;(3) State Research Center on Antibiotics, 113105 Moscow, Russia |
| Abstract: | The use of chemical and UV-induced mutageneses allowed us to increase the biosynthetic activity of the strain capable of producing new antistaphylococcal antibiotic, batumin. The strain ofPseudomonas batumici N17 producing 87–100 mg batumin per liter culture liquid was selected. Its activity was 3.5-5 times higher than the activity of the most potent natural strain.P. batumici N17 was shown to be stable in relation to the synthesis of batumin. |
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