Comparison of single- and three-stage tower loop reactors |
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Authors: | J Voigt K Schügerl |
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Institution: | 1. Institut für Technische Chemie der Universit?t Hannover, Callinstrasse 3, D-3000, Hannover, Germany
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Abstract: | Summary
Hansenula polymorpha was cultured for long periods in 254 cm high single and three-stage countercurrent tower loop reactors 20 cm in diameter
using ethanol as a substrate in the absence and presence of antifoam agents (Desmophen 3600 and/or soy oil). In the absence
of antifoam agents in the three-stage column, much higher volumetric mass transfer coefficients were attained than in the
corresponding single-stage column. The cell productivity in the former, however, was only slightly higher than in the single-stage
column due to considerable enrichment of the cells in the foam and nonuniform cell concentration distribution in the three-stage
column. In the presence of antifoam agents the three-stage column has a higher cell productivity, OTR, kL a and a lower specific energy requirement with regard to the absorbed oxygen and/or produced cell mass than the single stage
column. The reactor performance is especially high if the bubbling layer height is reduced to 20 cm. Soy oil has considerably
less foam eliminating property than Desmophen. Since the soy oil is metabolized by the yeast, large amounts are needed to
operate these reactors. |
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Keywords: | |
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