Residual Viral Replication during Antiretroviral Therapy Boosts Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses in Subjects Treated Early after Infection |
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Authors: | Gabriel M Ortiz Jennifer Hu Joshua A Goldwitz Rohit Chandwani Marie Larsson Nina Bhardwaj Sebastian Bonhoeffer Bharat Ramratnam Linqi Zhang Martin M Markowitz and Douglas F Nixon |
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Institution: | Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. gortiz@gladstone.ucsf.edu |
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Abstract: | Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have preserved HIV-1-specific CD4+ T-cell function. We studied the effect of highly active antiretroviral therapy (HAART) on the frequency of HIV-1-specific CD8+ T cells in patients treated during early (n = 31) or chronic (n = 23) infection. The degree of viral suppression and time of initiation of treatment influenced the magnitude of the CD8+ T-cell response. HIV-1-specific CD8+ T cells can increase in number after HAART in subjects treated early after infection who have episodes of transient viremia. |
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