Antimicrobial agents

In the microbial degradation of Fungicidin by lower pathogenic fungi, no significant differences were found in the rate of its degradation by the various species of dermatophytes employed (Trichophyton mentagrophytes, Trichophyton rubrum andMicrosporum gypseum), but there was a marked difference in the rate of enzymatic degradation by microorganisms adapted and not adapted to Fungicidin or Amphotericin B. After four hours' degradation of Fungicidin by non-adapted strains, about 70% of the Fungicidin in the medium was still intact, whereas it was completely degraded by adapted strains during the same interval. The addition of protein biosynthesis inhibitors (chloramphenicol and tetracycline) and of the antifungally active substance 2-aminotridecane did not influence the microbial degradation of Fungicidin by dermatophytes.