Nonparametric identification of the minimum effective dose |
| |
Authors: | Chen Y I |
| |
Institution: | Institute of Statistics, National Central University, Chung-Li, Taiwan. ychen@stat.ncu.edu.tw |
| |
Abstract: | We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonparametric procedure. Finally, the comparative results of a Monte Carlo level and power study for small sample sizes are presented and discussed. |
| |
Keywords: | Dose–response study Monte Carlo study One-way layout Step-down closed test |
本文献已被 PubMed 等数据库收录! |
|