树突状细胞迁移在肾小管间质炎症中作用及抗黏附干预调节

损伤因素刺激下产生的肾间质炎细胞浸润及肾小管间质炎症免疫反应,是导致和促进肾小管间质早期损伤、病变以及纤维化形成的重要原因。已证明炎症状态下的树突状细胞(DC)肾内迁移及其启动的炎症免疫反应与肾小管间质损害密切相关,既是导致肾间质纤维化形成的重要病理基础,也是肾脏局部免疫病理机制中的关键因素。鉴于选择素等黏附分子介导参与了DC肾内迁移及炎症免疫反应,而针对此的抗黏附调节已取得良好的干预效果,故可能不失为一个新的肾小管间质损伤及纤维化的防治途径和手段。

The Effect of Dendritic Cells Migration and Anti-adhesive Regulation on Renal Tubulointerstitial Inflammation

Inflammatory cells infiltration into renal interstitium and immune reaction stimulated by injury factors play key role in early stage of renal tubulointerstitial lesion and fibrosis. It has been proved that dendritic cells (DCs) migration into the renal tissue under the circumstances of inflammation and the inflammatory immune reaction triggered by DCs migration are closely relevant to the injury of renal tubulointerstitium. It is not only the pathologic basis of the fibrosis, but also the critical factor of renal immune pathologic mechanism. The adhesion molecules such as selectins contribute to DCs migration into the renal tissue and inflammatory immune reaction. And anti-adhesive regulation has achieved satisfactory results, which may be a new approach to preventing and treating the renal tubulointerstitial lesion and fibrosis.