Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142 USA ;Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142 USA
Abstract:
The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract