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Interactome analysis brings splicing into focus |
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| Authors: | Daniel Dominguez Christopher B. Burge |
| Affiliation: | Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142 USA ;Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142 USA |
| Abstract: | The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract |
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