Positive antibacterial co-action between hop (Humulus lupulus) constituents and selected antibiotics |
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Authors: | P Natarajan S Katta I Andrei V Babu Rao Ambati M Leonida GJ Haas |
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Institution: | aSchool of Natural Sciences, Fairleigh Dickinson University, Teaneck, NJ, USA;bL.V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, India;cBeilis Development, Fairlawn, NJ, USA |
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Abstract: | The research reported here deals with co-action of the hop (Humulus lupulus)-derived anti-bacterial compounds, lupulone and xanthohumol, with several antibiotics. Among the antibiotics investigated for their co-action, polymyxin B sulfate, tobramycin and ciprofloxacin had a positive co-action in inhibiting selected test bacteria. The disc/well-diffusion assay and the minimum inhibitory concentration test (MIC) were employed to determine co-action. Both Gram-positive and Gram-negative bacteria were used in the evaluation. There was some co-action against all Gram-positive bacteria tested. Surprisingly, there was some positive co-action even against certain Gram-negative bacteria but not against others. Particularly, there was no co-action against E.coli. An antibacterial cream with lupulone, neomycin and polymyxin B sulfate was prepared and showed co-action. Ideas for other practical applications of this effect are put forth. The mechanism of the synergistic effect is briefly discussed but no attempt was made to prove it experimentally. |
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Keywords: | Humulus lupulus Lupulone Xanthohumol Polymyxin B Ciprofloxacin Tobramycin Synergistic effects |
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