首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Positive antibacterial co-action between hop (Humulus lupulus) constituents and selected antibiotics
Authors:P Natarajan  S Katta  I Andrei  V Babu Rao Ambati  M Leonida  GJ Haas  
Institution:aSchool of Natural Sciences, Fairleigh Dickinson University, Teaneck, NJ, USA;bL.V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, India;cBeilis Development, Fairlawn, NJ, USA
Abstract:The research reported here deals with co-action of the hop (Humulus lupulus)-derived anti-bacterial compounds, lupulone and xanthohumol, with several antibiotics. Among the antibiotics investigated for their co-action, polymyxin B sulfate, tobramycin and ciprofloxacin had a positive co-action in inhibiting selected test bacteria. The disc/well-diffusion assay and the minimum inhibitory concentration test (MIC) were employed to determine co-action. Both Gram-positive and Gram-negative bacteria were used in the evaluation. There was some co-action against all Gram-positive bacteria tested. Surprisingly, there was some positive co-action even against certain Gram-negative bacteria but not against others. Particularly, there was no co-action against E.coli. An antibacterial cream with lupulone, neomycin and polymyxin B sulfate was prepared and showed co-action. Ideas for other practical applications of this effect are put forth. The mechanism of the synergistic effect is briefly discussed but no attempt was made to prove it experimentally.
Keywords:Humulus lupulus  Lupulone  Xanthohumol  Polymyxin B  Ciprofloxacin  Tobramycin  Synergistic effects
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号