Structural basis of the intracortical synchronization of epileptic potentials in the sensomotor region of the rat neocortex |
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Authors: | Pasikova N V Marchenko V G Kositsin N S |
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Institution: | Institute of Higher Nervous Activity and Neurophysiology, Russian Acad. Sci., Moscow, Russia. |
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Abstract: | In control rats, penicillin-induced epileptiform discharges were completely synchronous in the neocortex sites at a distance of up to 4 mm from each other. Number of the cells decreased by 45.5% during 90 days in isolated cortical slabs and the synchronisation disappeared. The data obtained show that the loss of large pyramidal neurones of the layer V entailed a loss of the spatial synchronisation. The main axonal collaterals of large pyramidal neurones of the layer V could be followed horizontally for a distance of up to 2 mm in the somatosensory cortex. The neuronal network formed by the large pyramidal neurones of the layer V seems to provide a spatial synchronisation in the neocortex. |
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