| 增龄对大鼠膈肌Glut-1和Glut-4 mRNA表达的影响 |
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| 引用本文： | 畅怡,聂秀红,曹若瑾,蔡彦宁,冯明. 增龄对大鼠膈肌Glut-1和Glut-4 mRNA表达的影响[J]. 中国实验动物学杂志, 2010, 0(8): 15-17 |
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| 作者姓名： | 畅怡 聂秀红 曹若瑾 蔡彦宁 冯明 |
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| 作者单位： | [1]首都医科大学宣武医院呼吸内科,北京100053 [2]首都医科大学宣武医院北京老年病研究所神经生物学研究室,北京100053 [3]首都医科大学宣武医院综合科,北京100053 |
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| 摘 要： | 目的研究大鼠膈肌Glut-1和Glut-4 mRNA的增龄变化情况,进一步探讨增龄对呼吸肌代谢及功能变化的机制。方法雄性健康清洁级SD大鼠24月龄7只、3月龄12只,应用RT-PCR方法检测大鼠膈肌Glut-1、Glut-4 mRNA表达。结果老年组大鼠Glut-1、Glut-4 mRNA表达较年轻组表达明显升高。结论大鼠膈肌不同于单纯骨骼肌和心肌,Glut-1、Glut-4 mRNA的表达具有特殊的增龄趋势。
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| 关 键 词： | 膈肌 葡萄糖转运蛋白 增龄 大鼠 |
Age-Related Changes of Glut-1 and Glut-4 mRNA Expression in the Rat Diaphragm |
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| CHANG Yi,NIE Xiu-hong,CAO Ruo-jin,CAI Yan-ning,FENG Ming. Age-Related Changes of Glut-1 and Glut-4 mRNA Expression in the Rat Diaphragm[J]. Chinese Journal of Laboratory Animal Science, 2010, 0(8): 15-17 |
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| Authors: | CHANG Yi NIE Xiu-hong CAO Ruo-jin CAI Yan-ning FENG Ming |
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| Affiliation: | 1.Department of Respiratory Medicine;2.Department of Molecular Neurology,Beijing Institute of Geriatrics;3.Department of Integrative Medicine,Beijing Xuanwu Hospital,Capital University of Medical Sciences,Beijing 100053,China) |
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| Abstract: | Objective The aim of this study was to investigate the age-related changes in Glut-1 and Glut-4 mRNA expression in the rat diaphragmatic muscle.Methods The expressions of Glut-1 and Glut-4 mRNA in the diaphragmatic muscle of SD rats（24 months old,n = 7;3 months old,n = 12） were analyzed by RT-PCR.Results In the aged groups,the expression of Glut-1 and Glut-4 mRNA in the diaphragmatic muscle was markedly higher than that in young groups.Conclusions There is a characteristic age-related tendency of Glut-1 and Glut-4 mRNA expression in the diaphragmatic muscle,different from that in the skeletal and cardiac muscles. |
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| Keywords: | Diaphragm Glucose transporter Aging Rat |
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