抵抗素的研究进展

抵抗素（resistin）是近年来发现的一个新脂肪细胞因子,最初在动物实验被用于联系肥胖、胰岛素抵抗和2型糖尿病。但随着进一步在人类实验的研究中发现,抵抗素能调节炎症反应而非胰岛素敏感性,研究发现抵抗素能促进炎症发生,炎症因子也能调节抵抗素的表达。动脉硬化是一种慢性亚临床性炎症,大量的体外研究提示抵抗素有可能作为一种促炎因子,通过激活内皮功能,诱导平滑肌增殖迁移,促巨噬细胞的脂质沉积,导致脂质代谢紊乱等途径,促进动脉粥样硬化的发生与发展。

Recent progress in Resistin

Resistin was found in recent years which is a new adipocytokine.It was initially thought to be a link in obesity,insulin resistance and type 2 diabetes mellitus in animal studies.However,recent researches found that resistin was mainly associated with in-flammation and not associated with insulin sensitivity in human.Atherosclerosis is a disease with low-grade inflammation.It has been shown recently that resistin plays a role in the development of atherosclerosis.Resistin as a pro-inflammation factor that could activate endothelial dysfunction,induce lipidoses in macrophages and promote smooth muscle cells proliferation and migration and dislipideamia pathway,so as to contribute to the atherogenic process.