兔先天性青光眼网络膜血管改变

目的　研究青光眼对视网膜脉络膜血液循环的影响。方法　选24月龄、体重3.5～4kg的先天性青光眼大耳白兔5只(7只眼)，选10只同龄大耳白兔作为对照组。另选10只2月龄、体重2kg大耳白兔前房内灌注生理盐水制成急性高眼压模型。对三组兔进行眼底照像、闪光视诱发电位(FVEP)检查，观察视网膜脉络膜血管形态和FVEP的变化。对人工急性高眼压组还进行了闪光视网膜电流图(FERG)检查。结果　先天性青光眼组与同龄对照组相比视网膜脉络膜末梢血管网明显减少；人工急性高眼压组眼压升高后首先使视网膜脉络膜末梢血管网灌流不足，随着眼压的继续升高脉络膜大血管变细，末梢血管网灌流不足加重，眼压极度升高时脉络膜大血管血流中断。同龄正常对照组的FVEP的主波P100潜伏期是(83±9)ms，先天性青光眼组则为(112±14)ms，差异有非常显著意义(P＜0.01)；人工急性高眼压组高眼压前为(69±5)ms，眼压60～80mm　Hg时延长为(81±7)ms，眼压在100～130mmHg时FVEP波形低平，近似直线；眼压恢复正常后2hFVEP的P100潜伏期为(82±8)ms。人工急性高眼压前后FERG变化显著。结论　青光眼可以影响视网膜脉络膜血液循环；可使FVEP、FERG发生变化。

The Changes of Retinal and Choroidal Blood Vessels of Congenital Glaucoma in Rabbits

Objective To investigate the ef fect of glaucoma on rabbitretinal and choroidal circulation.Methods Congenita l glaucoma group was composed of 5rabbits(7 eyes) of 24 months old，weighed 3.5 -4kg； control group： 10 rabbits with the same age； animal model group： 10 rabbits of 2 months old， weighted 2kg， its hyper tension developed by perfusing the anterior chamber with normal saline. Through the fundus photos and flash visual evoked potential (FVEP)， we observed the sh apes of retinal and choroidal blood vessels， and the changes of FVEP. Flash electroretinogram (FERG) was used in the man -made acute hypertension rabbits.Results Compared with the control group， the retinal and choroidal vessel endings of co ngenital glaucoma rabbits were obviously decreased. In man-made acute hypertens i on rabbits， acute elevation of intraocular pressure (IOP) firstly caused the is chemia of retinal and choroidal vessel endings， with the large blood vessels thinned， even the blood flow discontinued. FVEP P100 latent period： con trol (83 ±9) ms， congenital glaucoma (112±14) ms， the difference was significant (p<0 .0 1) ； man-made acute hypertension： (69±5) ms before the elevation of IOP， (81 ±7 ) ms at 60-80mmHg， the wave was similar to a line at 100-130mmHg， (82±8)ms at 2 hours after IOP was restored to normal. FERG changed abruptly before and after the hypertention.Conclusion Glaucoma may ef fect the retinal and choroidal circulation， and cause the changes of FVEP and FERG .