Effect of testosterone and progesterone on carboxypeptidase H activity during stress in mice |
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Authors: | Vernigora A N Saldaev D A Gengin M T |
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Affiliation: | V. G. Belinsky Penza State Pedagogical University, 37 Lermontov St., Penza 440028, Russia. |
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Abstract: | It was found that testosterone propionate (3 mg/kg of body weight) and progesterone (1 mg/kg of body weight) partially prevent an augmentation of the carboxypeptidase H activity in the mouse pituitary gland under stress caused by a single intraperitoneal administration of olive oil. In testicles, testosterone prevented augmentation of the enzyme activity within 0.5 hours but increased it through in 4 and 24 hours after treatment. Progesterone in testicles augmented the enzyme activity within 0.5 hours, but not in 4 and 24 hours. Sex steroids were not affected by stressinduced carboxypeptidase H activity in hypothalamus and adrenal medulla. It was concluded that carboxypeptidase H did not take part in integration of hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axis under the stress. |
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