Estudio de la sensibilidad especifica en residentes de un area endemica a la Paracoccidioidomicosis en Venezuela |
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| Authors: | María C. Bastardo de Albornoz Rafael M. Albornoz |
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| Affiliation: | (1) Cátedra de Dermatologîa. Sección Micologia. Escuela Vargas, Universidad Central de Venezuela, Venezuela;(2) Medico de Salud Pública. División de Dermatología Sanitaria, Ministerio de Sanidad y Asistencia Social. Caracas, Venezuela |
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| Abstract: | Resumen Se presenta el estudio de la reacción a la Paracoccidioidina de los habitantes de un área de alta incidencia de Micosis de Lutz y Splendore, encontrándose positividad en el 52% de los residentes. Se hizo simultáneamente intradermo-reacciones al P.P.D., Histoplasmina y Esporotriquina, encontrándose cierta correlación de resultados sólo con la Histoplasmina. Con fines de comparación se hizo encuesta en pequeño grupo de habitantes de otra área del pais, encontrándose una diferencia estadisticamente significante con los resultados de la zona en estudio. Se hacen varios comentarios.
Cutaneous sensitivity to paracoccidiodin was tested in 686 persons of an endemic area of Paracoccidioidomicosis in Venezuela. The antigen was prepared in our laboratory according to the technique used byFava Netto (Brasil). Skin-testing such as histoplasmin, sporotrichin and P.P.D. also were performed. Due to the high percentage obtained in the reading of the paracoccidioidin (52%) an inquiry was made in a not endemic area obtaining a percentage of 6,1%; this difference is statistically significant. Significant results are also obtained for the two remaining antigens of mycotic origin.Emphasis is laid on the importance of working with the same antigen used in Brasil.Commentaries are made on the common reactions that occur between paracoccidioidin and histoplasmin, and on the possibility of interpreting them as crossed reactions or that the same person is sensitive to the two agents which are in the environment of the place where they live.No crossed reactions were found between sporotrichin and paracoccidioidin in a significant number of cases, nor between the latter and the P.P.D. and this is considered very important in connection with the active or residual possible pulmonary lesions that could be seen in the persons with negative P.P.D.The appearance of positive reactions to paracoccidioidin was observed by beginning at the age of 10 and becoming more intense at 20 and it is higher in males than in females.
Trabajo realizado con la ayuda económica de la FundaciónJose Maria Vargas. |
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