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Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors |
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| Authors: | Wang Shudong Wood Gavin Meades Christopher Griffiths Gary Midgley Carol McNae Iain McInnes Campbell Anderson Sian Jackson Wayne Mezna Mokdad Yuill Rhoda Walkinshaw Malcolm Fischer Peter M |
| Institution: | Cyclacel Limited, James Lindsay Place, Dundee DD1 5JJ, Scotland, UK. swang@cyclacel.com |
| Abstract: | A series of 2-anilino-4-(1H-pyrrol-3-yl)pyrimidines were prepared and evaluated for their ability to inhibit cyclin-dependent kinases (CDKs). A number of analogues were found to be potent CDK2 and CDK4 inhibitors and to exhibit anti-proliferative activity against human tumour cell lines. Structure-activity relationships and biochemical characterization are presented. |
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