脂肪因子Chemerin与妊娠相关疾病的关系展望

<正>1 Introduction Recurrent pregnant loss,gestational diabetes,premature delivery,intrauterine growth restriction,preeclampsia and other pregnancy-related complications have severe impact on the fetus development and the health and life quality of the mother.These diseases are also causes of unstability and huge economic burden for the family as well as the

The Role of Adipokine Chemerin in Pregnancy Complications

Pregnancy complications, such as, recurrent pregnancy loss, gestational diabetes mellitus, preterm labor, intrauterine growth restriction and preeclampsia, greatly impaired the health and quality of daily life of pregnant women and neonatal. However, the etiology of most of the pregnancy complications is still unclear. Recently, appearing in younger population and increasing incidence of lipid and carbohydrate metabolism disorders, such as obesity and diabetes, will lead to increasing reproductive health issues in this population. Studies have shown that the pregnancy complications are correlated with lipid and carbohydrate metabolism disorders and hypertension, but the internal links are still unclear. Adipokine Chemerin was involved with both of the metabolism disorders and hypertension, so as abnormal expressed in pregnancy complications. However, whether it is the cause of pathogenesis of pregnancy complications or not, is still unclear. To address the possible etiological role of Chemerin with pregnancy complications, we summarized the research advance of Chemerin on pregnancy and pregnancy complications studies and combined with the findings in the pathogenesis of Chemerin with metabolism disorders and hypertension. This review will provide new ideas and directions for pregnancy complication investigations.