The protective effect of a purified extract of <Emphasis Type="Italic">Withania somnifera</Emphasis> against doxorubicin-induced cardiac toxicity in rats |
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Authors: | A Hamza A Amin S Daoud |
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Institution: | (1) Biology Department, College of Science, U.A.E. University, Al-Ain, United Arab Emirates;(2) Department of Pathology, Twam Hospital, Al-Ain, United Arab Emirates;(3) Biology Department, U.A.E. University, Al-Ain, P.O. Box 17551, United Arab Emirates |
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Abstract: | The therapeutic value of doxorubicin as an effective antineoplastic agent is limited by its cardiotoxic side-effects. The
administration of doxorubicin (10 mg/kg) to male Wistar rats induced necrosis and apoptosis in heart tissues. It also caused
oxidative stress damage as evidenced by the elevation of malondialdehyde and protein carbonyl levels and catalase activity,
accompanied by the concurrent depletion of total antioxidant capacity and of superoxide dismutase level in cardiac tissues.
The doxorubicin-induced cardiotoxicity and oxidative stress damage were also accompanied by increases of myeloperoxidase activity,
total calcium content, and the expression of Bcl-2 protein in heart tissues. Most of these doxorubicin-induced biochemical
and histological alterations were effectively attenuated by prior administration of purified standardized extract (1.5% withanolides;
manufactured by Idea Sphere Inc., American Fork, UT, USA) of Withania somnifera (300 mg/kg). Thus, Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is
the cancer-treating drug. |
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Keywords: | Doxorubicin Cardiotoxicity Protection Withania Apoptosis |
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