Comparison of acetate inhibition on growth of host and recombinantE. coli K12 strains |
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| Authors: | Boon Tong Koh Utaka Nakashimada Marco Pfeiffer Miranda G. S. Yap |
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| Affiliation: | (1) Bioprocessing Technology Unit, National University of Singapore, 10 Kent Ridge Crescent, 0511, Singapore;(2) Department of Chemical of Engineering, National University of Singapore, 10 Kent Ridge Crescent, 0511, Singapore;(3) Department of Biotechnology, Faculty of Engineering, Nagoya University, Nagoya 464, Japan;(4) Fachbereich 8 Bio-Ingenieurwesen, Prodktionstechnik und Verfahrenstechnik, Facnochschule Hamburg, PH Hamburg, FB 8 Lohbrugger Kircgstr, 65, 2050 Hamburg 80, Germany |
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| Abstract: | Summary We investigated the extent of acetate inhibition on growth rate of different host and recombinantE. coli K12 strains, cultivated in defined and complex media. A mathematical model was proposed to describe this inhibition. Our results show that acetate inhibition is more significant for recombinant cells than for host cells, and for cells cultured in defined medium than in complex medium. |
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