Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system |
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| Authors: | Chandra P Zimmer C Thrum H |
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| Affiliation: | Institut für Therapeutische Biochemie der Universit?t, Frankfurt an Main, GDR |
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| Abstract: | It is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA-polymerase system is due to the interference of the antibiotic with DNA. |
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