Amurensiosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis |
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| Authors: | Minpei Kuroda Satoshi Kubo Hiroshi Sakagami |
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| Institution: | a School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan
b Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyaki-dai, Sakado, Saitama 350-0283, Japan |
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| Abstract: | Five new pregnane tetraglycosides, amurensiosides A-E (1-5), two new pregnane hexaglycosides, amurensiosides F (6) and I (9), two new 18-norpregnane hexaglycosides, amurensiosides G (7) and H (8), and two new pregnane octaglycosides, amurensiosides J (10) and K (11), were isolated from the MeOH extract of the roots of Adonis amurensis. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 human oral squamous cell carcinoma cells. |
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| Keywords: | Adonis amurensis Ranunculaceae Pregnane glycosides Amurensiosides A-K Cytotoxic activity HSC-2 cells |
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