Antiviral flavonoids from the root bark of Morus alba L |
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| Authors: | Du Jiang He Zhen-Dan Jiang Ren-Wang Ye Wen-Cai Xu Hong-Xi But Paul Pui-Hay |
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| Affiliation: | Department of Biology and Chemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China. |
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| Abstract: | A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods. |
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| Keywords: | Morus alba Moraceae Moralbanone Leachianone Mulberroside Flavonoid Antiviral Herpes |
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