Self-Microemulsifiyng Suppository Formulation of β-Artemether |
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Authors: | Dalapathi Gugulothu Sulabha Pathak Shital Suryavanshi Shobhona Sharma Vandana Patravale |
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Institution: | (1) Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai , 400019, India;(2) Molecular Parasitology Lab, B 332, Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai, 400005, India; |
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Abstract: | Parasitic diseases are of immense global significance as around 30% of world’s population experiences parasitic infections.
Among these, malaria is the most life-threatening disease. Various routes of administration have been explored for delivering
antimalarial actives. The present investigation aims at formulating self-microemulsifying suppositories of β-artemether with
faster onset of action and prolonged effect to be administered by rectal route. These were compared with conventional polyethylene
glycol suppositories with respect to melting range, rheology, texture analysis, disintegration time, self microemulsification
time, particle size, and drug content. In vitro drug release was studied by using USP apparatus II. Further, the suppositories were evaluated in murine model against virulent
rodent malaria parasite Plasmodium berghei wherein the developed self-microemulsifying suppositories could sustain the activity (94%) for 20 days post infection. The
survival of animals was also better as compared to the conventional formulation. |
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