Proteomic analysis of streptomycin resistant and sensitive clinical isolates of Mycobacterium tuberculosis |
| |
| Authors: | Prashant Sharma Bhavnesh Kumar Yash Gupta Neelja Singhal Vishwa Mohan Katoch Krishnamurthy Venkatesan Deepa Bisht |
| |
| Affiliation: | 1.Department of Biochemistry,National JALMA Institute for Leprosy and Other Mycobacterial Diseases,Agra,India;2.Department of Microbiology & Molecular Biology,National JALMA Institute for Leprosy and Other Mycobacterial Diseases,Agra,India;3.Secretary, Department of Health Research, Government of India & Director-General,Indian Council of Medical Research,New Delhi,India |
| |
| Abstract: | Background Streptomycin (SM) is a broad spectrum antibiotic and is an important component of any anti-tuberculosis therapy regimen. Several mechanisms have been proposed to explain the emergence of resistance but still our knowledge is inadequate. Proteins form a very complex network and drugs are countered by their modification/efflux or over expression/modification of targets. As proteins manifest most of the biological processes, these are attractive targets for developing drugs, immunodiagnostics or therapeutics. The aim of present study was to analyze and compare the protein profile of whole cell extracts from Mycobacterium tuberculosis clinical isolates susceptible and resistant to SM. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
