An information-flow-based model with dissipation,saturation and direction for active pathway inference |
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| Authors: | Xianwen Ren Xiaobo Zhou Ling-Yun Wu Xiang-Sun Zhang |
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| Affiliation: | (1) Academy of Mathematics and Systems Science, Chinese Academy of Sciences, 100190 Beijing, China;(2) Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, 77030 Houston, TX, USA |
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| Abstract: | Background Biological systems process the genetic information and environmental signals through pathways. How to map the pathways systematically and efficiently from high-throughput genomic and proteomic data is a challenging open problem. Previous methods design different heuristics but do not describe explicitly the behaviours of the information flow. |
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