Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa |
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| Authors: | Ahmad Ijaz Chen Shilin Peng Yong Chen Sibao Xu Lijia |
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| Affiliation: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing, China. drijaz_chem@yahoo.com |
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| Abstract: | Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1-7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC(50) value of 39.7 +/- 0.02microM, along with DPPH radical scavenging activity with IC(50) value 0.638 mM. |
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