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Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Authors:Tina Cascone  Jodi A. McKenzie  Rina M. Mbofung  Simone Punt  Zhe Wang  Chunyu Xu  Leila J. Williams  Zhiqiang Wang  Christopher A. Bristow  Alessandro Carugo  Michael D. Peoples  Lerong Li  Tatiana Karpinets  Lu Huang  Shruti Malu  Caitlin Creasy  Sara E. Leahey  Jiong Chen  Weiyi Peng
Affiliation:1. Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;3. Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;4. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;5. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;6. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;7. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;8. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;9. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA;10. Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Abstract:
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  • Keywords:tumor metabolism reprogramming  glycolysis  adoptive T cell therapy  immune resistance  cancer immunotherapy  melanoma  non-small cell lung cancer
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