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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
Authors:Graeme I Lancaster  Katherine G Langley  Nils Anton Berglund  Helene L Kammoun  Saskia Reibe  Emma Estevez  Jacquelyn Weir  Natalie A Mellett  Gerard Pernes  James RW Conway  Man KS Lee  Paul Timpson  Andrew J Murphy  Seth L Masters  Steve Gerondakis  Nenad Bartonicek  Dominik C Kaczorowski  Marcel E Dinger  Mark A Febbraio
Institution:1. Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia;2. Department of Immunology, Monash University, Melbourne, VIC 3004, Australia;4. Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia;5. Faculty of Medicine, St Vincent''s Clinical School, Faculty of Medicine, University of NSW, Sydney, NSW 2010, Australia;6. Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia;7. Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia;8. Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore;9. Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia;10. Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Abstract:
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  • Keywords:inflammation  innate immunity  toll-like receptors  metabolism  obesity
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