Silicon Supplementation Improves the Bone Mineral Density of Calcium-Deficient Ovariectomized Rats by Reducing Bone Resorption |
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Authors: | Mi-Hyun Kim Yun-Jung Bae Mi-Kyeong Choi Yoon-Sok Chung |
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Institution: | (1) Department of Food and Nutrition, Kangwon National University, San 253 Gyo-dong, Samcheok-si, Gangwondo, 245-711, South Korea;(2) Department of Food and Nutrition, Sookmyung Women’s University, Seoul, 140-742, South Korea;(3) Department of Human Nutrition and Food Science, Chungwoon University, Chungnam, 350-701, South Korea;(4) Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, 443-749, South Korea |
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Abstract: | The purpose of this study was to investigate the effect of silicon (Si) supplementation on bone mineral density (BMD) and
bone metabolism parameters relative to calcium (Ca) intake levels in ovariectomized rats. A total of 72 female Wistar rats
(6 weeks) were ovariectomized (OVX) and divided into six groups, and Si (500 mg of Si per kilogram of feed) was or was not
administered with diets containing various levels of Ca (0.1%, 0.5%, and 1.5%) for 10 weeks. The groups were as follows: (1)
Ca-deficient group (0.1% Ca), (2) Ca-deficient with Si supplementation group, (3) adequate Ca group (0.5% Ca), (4) adequate
Ca with Si supplementation group, (5) high Ca group (1.5% Ca), and (6) high Ca with Si supplementation group. Si supplementation
significantly increased the BMD of the femur and tibia in Ca-deficient OVX rats, while no change was observed with Si supplementation
in the BMD of the spine, femur, and tibia in the adequate and high Ca groups. Serum alkaline phosphatase and osteocalcin levels
were not affected by Si supplementation or Ca intake levels. C-telopeptide type I collagen levels were significantly decreased
as a result of Si supplementation in Ca-deficient OVX rats. In summary, Si supplementation produced positive effects on bone
mineral density in Ca-deficient OVX rats by reducing bone resorption. Therefore, Si supplementation may also prove to be helpful
in preventing osteoporosis in postmenopausal women whose calcium intake is insufficient. |
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Keywords: | Silicon supplementation Ca deficient Bone mineral density Osteocalcin CTX Urinary calcium Ovariectomy (rat) |
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