Suppression of lymphocyte stimulation by anterior hypothalamic lesions in the guinea pig |
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| Authors: | Steven E Keller Marvin Stein Maria S Camerino Steven J Schleifer Jeffrey Sherman |
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| Institution: | Department of Psychiatry, Mount Sinai School of Medicine, City University of New York, New York, New York 10029 USA |
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| Abstract: | Anterior hypothalamic lesions in the guinea pig inhibited lymphocyte stimulation in whole blood cultures with the antigen tuberculin and with the mitogen phytohemagglutinin (PHA) and suppressed the delayed cutaneous hypersensitivity response to tuberculin. The lesions did not affect the stimulation of purified lymphocytes with either tuberculin or PHA. The anterior hypothalamic lesions had no effect on the absolute number of T and B lymphocytes. |
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