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The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase B |
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| Authors: | Magda Gioia Susanna Monaco Philippe E Van Den Steen Giuseppe Grasso Stefano Marini Christopher M Overall Ghislain Opdenakker |
| Institution: | 1 Department of Experimental Medicine and Biochemical Sciences, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Rome, Italy 2 Department of Oral Biological and Medical Sciences, Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T1Z3 3 Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T1Z3 4 Interuniversity Consortium for the Research on the Chemistry of Metals in Biological Systems, P.za Umberto I 1, I-70100 Bari, Italy 5 Rega Institute for Medical Research, Laboratory of Immunobiology, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium 6 Department of Chemistry, University of Catania, V.le A. Doria, Catania, Italy 7 Institute of Biostructure and Bioimaging, CNR, V.le A. Doria, Catania, Italy |
| Abstract: | |
| Keywords: | MMP matrix metalloproteinase MMP2 gelatinase A MMP9 gelatinase B CBD collagen binding domain MCA (7-methoxycoumarin-4-yl)acetyl DPA N-3-(2 l-2" target="_blank">4-dinitrophenyl)-l-2 3-diaminopropionyl PDMS poly(dimethylsiloxane) DMSO dimethyl sulfoxide SPR surface plasmon resonance SPRI surface plasmon resonance imaging NC1 domain noncollagenous domain MS mass spectrometry EHS Engelbreth-Holm-Swarm LPS lipopolysaccharide OPD orthophenylendiamine PBS phosphate-buffered saline |
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