Anthraquinones from the stem bark of Stereospermum zenkeri with antimicrobial activity |
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| Authors: | Lenta Bruno N Weniger Bernard Antheaume Cyril Noungoue Diderot T Ngouela Silvère Assob Jules C N Vonthron-Sénécheau Catherine Fokou Patrice A Devkota Krishna P Tsamo Etienne Sewald Norbert |
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| Affiliation: | Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon. |
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| Abstract: | Two anthraquinones, zenkequinones A and B were isolated from the stem bark of Stereospermum zenkeri together with known sterequinone-F, p-coumaric acid, sitosterol-3-O-beta-D-glucopyranoside and 3beta-hydroxyolean-12-en-28-O-beta-D-glucopyranoside. Their structures were established by spectroscopic methods. The antimicrobial activity of the isolated compounds was evaluated against six multiresistant strains of pathogens. Zenkequinone B showed the best antibacterial activity (MIC 9.50 microg/ml) against gram-negative Pseudomonas aeruginosa. |
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