LOW LEVEL INCORPORATION OF TRITIATED THYMIDINE INTO THE NUCLEAR DNA OF PURKINJE NEURONS OF ADULT MICE |
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| Authors: | I L Cameron Mary R H Pool T R Hoage |
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| Institution: | Department of Anatomy, The University of Texas Health Science Center, San Antonio, Texas and Department of Life Sciences, Sam Houston State University, Huntsville, Texas, U.S.A. |
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| Abstract: | Adult mice were pulse labeled with tritiated thymidine 3H]TdR and killed 9 hr later. A low level incorporation of 3H]TdR into the nuclear DNA of Purkinje neurons was found in autoradiographs. Enzymatic digestions with DNase and with RNase in combination with autoradiographic grain counts indicate that a portion of nuclear DNA is not stable in the Purkinje nucleus. These results are discussed in light of reports of the stable nature of DNA in Purkinje neurons of adult mice. |
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