Xanthones from a microfungus of the genus Xylaria |
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Authors: | Healy Peter C Hocking Ailsa Tran-Dinh Nai Pitt John I Shivas Roger G Mitchell Jennifer K Kotiw Mike Davis Rohan A |
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Affiliation: | Chemical Biology Program, Eskitis Institute, Griffith University, Nathan Campus, Brisbane, QLD 4111, Australia. |
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Abstract: | Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1-3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens. |
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Keywords: | Microfungus Xylaria sp. Rainforest tree Glochidion ferdinandi Natural products Secondary metabolites Xanthone |
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