|
|||||
|
|
Biotransformation of Methylphenylacetonitriles by Brazilian Marine Fungal Strain Aspergillus sydowii CBMAI 934: Eco-friendly Reactions |
|
| Authors: | Julieta Rangel de Oliveira Mirna Helena Regali Seleghim André Luiz Meleiro Porto |
| Institution: | 1. Instituto de Química de S?o Carlos, Universidade de S?o Paulo, Av. Trabalhador S?o-carlense, 400, CP 780, CEP 13560-970, S?o Carlos, SP, Brazil 3. Departamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes s/n, Cidade Universitária, Recife, CEP 50740-5460, PE, Brazil 2. Departamento de Ecologia e Biologia Evolutiva, Universidade Federal de S?o Carlos, Via Washington Luís, Km 235, S?o Carlos, SP, CEP 13565-905, Brazil |
| Abstract: | This study reports the biotransformation of methylphenylacetonitriles by Brazilian marine filamentous fungus Aspergillus sydowii CBMAI 934 under eco-friendly reaction conditions. The phenylacetonitrile 1, 2-methylphenylacetonitrile 2, 3-methylphenylacetonitrile 3, and 4-methylphenylacetonitrile 4 were quantitatively biotransformed into 2-hydroxyphenylacetic 1a, 2-methylphenylacetic acid 2a, 3-methylphenylacetic acid 3a, and 4-methylphenylacetic acid 4a by enzymatic processes using whole cell as biocatalyst. The marine fungus A. sydowii CBMAI 934 is thus a promising biocatalyst for the preparation of important carboxylic acids under mild conditions (pH 7.5 and 32 °C) from nitrile compounds. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |