EG-626: Not a thromboxane A2 antagonist, but a PGI2 potentiator in platelet aggregation |
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Authors: | Kunio Tanaka Yoshiteru Harada Makoto Katori |
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Affiliation: | Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228, Japan |
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Abstract: | Intracerebroventricular administration of PGI2 or PGE2 reduced aconitine-induced cardiac arrhythmia in rats. PGF2α had no antiarrhythmic effect under the same conditions. The ED50 values of PGI2 and E2 were 0.25 μg/kg and 1.1 μg/kg, respectively. Central mechanisms may participate in the antiarrhythmic effect of these PGs. |
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