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EG-626: Not a thromboxane A2 antagonist, but a PGI2 potentiator in platelet aggregation
Authors:Kunio Tanaka   Yoshiteru Harada  Makoto Katori
Affiliation:Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228, Japan
Abstract:Intracerebroventricular administration of PGI2 or PGE2 reduced aconitine-induced cardiac arrhythmia in rats. PGF had no antiarrhythmic effect under the same conditions. The ED50 values of PGI2 and E2 were 0.25 μg/kg and 1.1 μg/kg, respectively. Central mechanisms may participate in the antiarrhythmic effect of these PGs.
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