Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line |
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| Authors: | Cimmino Flora Spano Daniela Capasso Mario Zambrano Nicola Russo Roberta Zollo Massimo Iolascon Achille |
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| Institution: | Dipartimento di Biochimica e Biotecnologie Mediche, Universita'di Napoli Federico II, Centro di Ingegneria Genetica CEINGE- Biotecnologie Avanzate, Napoli, Italy. |
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| Abstract: | Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer. |
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