An edited linkage map for the AXB and BXA recombinant inbred mouse strains |
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| Authors: | Stephen B Sampson David C Higgins Rosemary W Elliot Benjamin A Taylor Kira K Lueders Robert A Koza Beverly Paigen |
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| Institution: | (1) The Jackson Laboratory, Bar Harbor, Maine 04609, USA, US;(2) Roswell Park Cancer Institute, Buffalo, New York 14263, USA, US;(3) Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA, US |
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| Abstract: | We have updated the history of the AXB and BXA recombinant inbred (RI) strains, typed additional loci, and edited the AXB,
BXA RI database. Thirteen of the original 51 AXB and BXA RI strains are either extinct or genetically contaminated, leaving
33 living strains available from The Jackson Laboratory. However, we found a high degree of similarity among three sets of
strains, indicating that these strains are not independent, which leaves 27 independent RI strains in the set. Accordingly,
we modified the database by combining the AXB and BXA RI sets and eliminating strains that were genetically contaminated or
extinct with no available DNA. We added 92 newly typed loci, retyped some questionable genotypings, and removed loci with
excessive double crossovers or an insufficient number of typed strains. The edited strain distribution pattern (SDP) is available
on the World Wide Web (WWW) (http://www.informatics.jax.org/riset.html) and now includes over 700 loci. Each locus is linked
to adjacent loci with a LOD score of at least 3.0 with a few described exceptions. We also carried out a second editing designed
for the analysis of quantitative trait loci by deleting extinct strains and loci with identical SDPs; this edited database
is also available on the WWW.
Received: 20 March 1998 / Accepted: 26 May 1998 |
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