Serum vascular endothelial growth factor C level in patients with prostate cancer and benign prostatic hyperplasia |
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Authors: | Voss Martin Trojan Lutz Steidler Annette Weiss Christel Grobholz Rainer Alken Peter Michel Maurice Stephan |
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Institution: | Department of Urology, University Hospital Mannheim, Mannheim, Germany. |
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Abstract: | OBJECTIVE: To compare serum vascular endothelial growth factor C (VEGF-C) levels in patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and analyze VEGF-C levels in relation to clinicopathologic parameters. STUDY DESIGN: Fifty-eight patients with PCa and 61 patients with BPH were included in this study. Serum VEGF-C levels were assessed by enzyme-linked immunosorbent assay. RESULTS: The serum VEGF-C level for patients with PCa was 3,432.06 +/- 1,851.07 as opposed to 3,166.68 +/- 1,921.2 for patients with BPH. There was no statistically significant difference between the 2 groups (p = 0.4448). There was no correlation of VEGF-C to tumor stage, grading or the preoperative prostate-specific antigen values. CONCLUSION: We cannot recommend VEGF-C serum level as a marker for tumor growth in PCa. |
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