Role of reactive oxygen species (ROS) in apoptosis induction |
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| Authors: | H.-U. Simon A. Haj-Yehia F. Levi-Schaffer |
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| Affiliation: | (1) Department of Pharmacology, University of Bern, Bern, Switzerland;(2) Department of Pharmaceutics, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel |
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| Abstract: | Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells. |
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| Keywords: | apoptosis death receptors inflammation reactive oxygen species (ROS) |
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