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New tetrazole-based selective anandamide uptake inhibitors |
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| Authors: | Ortar Giorgio Schiano Moriello Aniello Cascio Maria Grazia De Petrocellis Luciano Ligresti Alessia Morera Enrico Nalli Marianna Di Marzo Vincenzo |
| Institution: | aDipartimento di Studi Farmaceutici, ‘Sapienza’ Università di Roma, piazzale Aldo Moro 5, 00185 Roma, Italy bIstituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy cIstituto di Cibernetica, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy |
| Abstract: | A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC50 = 2.3–5.1 μM) and selectively over other proteins involved in endocannabinoid action and metabolism. |
| Keywords: | Endocannabinoids Anandamide uptake Anandamide uptake inhibitors Tetrazoles |
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