|
|||||
|
|
N,O-bisFmoc derivatives of N-(2-hydroxy-4-methoxybenzyl)-amino acids: Useful intermediates in peptide synthesis |
|
| Authors: | Tony Johnson Martin Quibell Robert C. Sheppard |
| Abstract: | 2-Hydroxy-4-methoxybenzyl-amino acid residues inhibit interchain association in solid phase peptide synthesis. They are easily introduced through their N,O-bisFmoc derivatives. Preparation of a range of these derivatives is described. |
| Keywords: | 2-Hydroxy-4-methoxybenzyl-amino acids Hmb-derivatives peptide synthesis solid phase synthesis difficult sequences |